Jane and Larry Glazer had been flying from New York to Florida
An unresponsive private plane has crashed in the sea off Jamaica, officials on the island have said.
The Jamaican Defence Force said the plane went down about 14 miles (22km) north-east of Port Antonio.
The US had earlier scrambled two F-15 fighter jets when the plane failed to respond to air traffic control.
The two people known to be on board have been named as Larry Glazer, a property developer from Rochester, New York, and his wife Jane.
The couple were both licensed pilots.
The plane's pilot had indicated there was a problem and twice asked to descend to a lower altitude before permission was granted, according to a recording of the radio conversation with US traffic controllers.
1. Plane departs 08:26 local time Friday 2. F16s scambled at 10:00 3. Plane passes destination; F15s take over observation 4. Cuba authorises US fly-over 5. Suspected crash site
Contact with the plane was lost a short time later.
Maj Basil Jarrett of the Jamaican Defence Force told reporters that an oil slick had been spotted about 14 miles north-east of the coastal town of Port Antonio but there was no sign yet of any wreckage.
He said search and rescue teams were scouring the waters for possible survivors.
As darkness fell, Jamaica suspended the search until first light on Saturday.
The plane, a Socata TBM-700 built in 2014, took off from Rochester at 08:26 (12:26 GMT) en route to Naples, Florida.
The North American Aerospace Defence Command (Norad) was alerted to the unresponsive plane about an hour into its flight and sent two fighter jets to monitor it.
A spokesman said it was not possible for the fighter pilots to see inside the plane as the windows were frosted or fogged over.
'Devastated'
A tweet from Norad suggested the pilot or pilots could have been be unresponsive due to "possible hypoxia" - oxygen deprivation.
On a recording made by LiveATC - a website that monitors air traffic control recordings - and quoted by the Associated Press, the pilot can be heard saying: "We need to descend to about (18,000 feet). We have an indication that's not correct in the plane."
Two F-15 fighter jets, like these shown, were sent to shadow the plane
A controller replies: "Stand by." After a pause, the controller tells the pilot to fly at 25,000ft.
"We need to get lower," the pilot responded.
"Working on that," the controller says.
Controllers then clear the plane to descend to 20,000ft and the pilot acknowledges the command.
Jamaican marine police returned to Port Antonio after a search for the missing plane
Minutes later a controller asks the plane to identify itself. There is no response.
According to FlightAware, the plane never carried out the last descent to 20,000ft.
New York Governor Andrew Cuomo paid tribute to the couple.
"The Glazers were innovative and generous people who were committed to revitalising downtown Rochester," he said.
The couple's three children said in a statement they were "devastated".
The US Federal Aviation Administration said it co-operated with Cuba air traffic control in monitoring the plane, despite the countries not having full diplomatic relations for more than half a century.
Cuba said it had authorised the US military to fly a C-130 cargo plane and two fighter jets over its airspace to investigate the incident.
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